Thymidine Kinase-1 As A Biomarker in Breast Cancer: Estimating Prognosis and Early Recognition of Treatment Resistance

医学 帕博西利布 来曲唑 乳腺癌 肿瘤科 内科学 梅德林 癌症 三苯氧胺 转移性乳腺癌 政治学 法学
作者
Amelia McCartney,Luca Malorni
出处
期刊:Biomarkers in Medicine [Future Medicine]
卷期号:14 (7): 495-498 被引量:7
标识
DOI:10.2217/bmm-2020-0072
摘要

Biomarkers in MedicineVol. 14, No. 7 EditorialThymidine kinase-1 as a biomarker in breast cancer: estimating prognosis and early recognition of treatment resistanceAmelia McCartney & Luca MalorniAmelia McCartney https://orcid.org/0000-0003-0411-0736“Sandro Pitigliani” Medical Oncology Department, Hospital of Prato, Prato, ItalySearch for more papers by this author & Luca Malorni*Author for correspondence: Tel.: +39 0574 802 520; Fax: +39 0574 802 903; E-mail Address: luca.malorni@uslcentro.toscana.it“Sandro Pitigliani” Medical Oncology Department, Hospital of Prato, Prato, Italy“Sandro Pitigliani” Translational Research Unit, Hospital of Prato, Prato, ItalySearch for more papers by this authorPublished Online:7 May 2020https://doi.org/10.2217/bmm-2020-0072AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: biomarkerbreast cancerCDK4/6endocrine therapyluminal, prognosismetastaticresistancethymidine kinase-1TK1References1. 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Thymidine kinase 1 is a better prognostic marker than Ki-67 for pT1 adenocarcinoma of the lung. Int. J. Clin. Exp. Med. 7(8), 2120–2128 (2014).Medline, Google Scholar26. Wang J, Liu Q, Zhou X et al. Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: a new prognostic biomarker. Tumour Biol. 39(6), 1010428317706479 (2017).Crossref, Google Scholar27. Juric D, Janku F, Rodón J et al. Alpelisib plus fulvestrant in PIK3CA-altered and PIK3CA-wild-type estrogen receptor-positive advanced breast cancer: a Phase 1b clinical trial. JAMA Oncol. 5(2), e184475 (2019).Crossref, Medline, Google Scholar28. André F, Ciruelos E, Rubovszky G et al. Alpelisib for PIK3CA-mutated, hormone receptor-positive advanced breast cancer. N. Engl. J. Med. 380(20), 1929–1940 (2019).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByTK1 is an early screening marker for uterine corpus endometrial carcinoma and promotes its progressionGene Reports, Vol. 31Serum thymidine kinase activity in patients with HR-positive/HER2-negative advanced breast cancer treated with ribociclib plus letrozole: results from the prospective BioItaLEE trialEuropean Journal of Cancer, Vol. 9 Vol. 14, No. 7 Follow us on social media for the latest updates Metrics Downloaded 160 times History Received 12 February 2020 Accepted 25 March 2020 Published online 7 May 2020 Published in print May 2020 Information© 2020 Future Medicine LtdKeywordsbiomarkerbreast cancerCDK4/6endocrine therapyluminal, prognosismetastaticresistancethymidine kinase-1TK1Financial & competing interests disclosureThis work was partially supported by a grant from the Breast Cancer Research Foundation (grant number BCRF 19-037) and by a grant from Fondazione AIRC (IG 22869). L Malorni has received research support from Novartis and Pfizer and is a consultant for Eli Lilly, Pfizer and Novartis. Both authors have academically collaborated with Biovica International without any financial remuneration or contractual agreement. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript, apart than those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
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