Four new benzoyltyramines from the peels of Atalantia monophylla and their cytotoxicity

Four new benzoyltyramines, atalantums H-K ( 1-4 ) [ [ 1 ] ] , and seven known compounds ( 5-11 ) [ [ 2 ] ] were isolated from the peels of Atalantia monophylla . All compounds were tested for cytotoxicity against HeLa, HCT116 and MCF-7 cell lines, as well as normal cells (Vero cells). Compound 5 showed cytotoxicity against HeLa, HCT116 and MCF-7 cell lines with IC 50 values ranging from 16-25 µ g/mL but was inactive against Vero cells. Compound 6 also showed interesting results as compound 5 with IC 50 values ranging from 15-18 µ g/mL and an IC 50 value of 80.2 µ g/mL against Vero cells. This means compounds 5 and 6 can be used as lead compounds for anticancer agents. Fig. 1