Progress of NF-κB signaling pathway in COPD

Nuclear factor of kappa B (NF-κB) is a kind of widespread nuclear transcription regulatory proteins, and it regulates the expression of multiple genes, including inflammation, immunity, cell proliferation, differentiation and apoptosis.The activation of NF-κB signaling pathway is closely related to the genesis and development of COPD.Inhibiting the activating of NF-κB signaling pathways become the new target for treatment of COPD.Now it has been found that a variety of drugs can inhibit the activating of NF-κB signaling pathways by intervening in different sites of NF-κB signaling pathway, which can be used in the treatment of COPD.This paper reviews the NF-κB and the activation and inhibition of its signal pathway, the pathogenesis of NF-κB signal pathway in COPD, and the treatment of various drugs in COPD by blocking NF-κB signaling pathways. Key words: Nuclear factor of kappa B; Signal pathway; Chronic obstructive pulmonary disease