Research advances in signal pathway and molecular mechanism of vascular calcification

Vascular disease, such as atherosclerosis and diabetic vasculopathy, is frequently complicated by vascular calcification. Previously believed to be an end-stage process of unregulated mineral precipitation, it is now well established to be a multi-faceted disease. The numerous regulatory signaling pathways that influence vascular calcification, and these pathways are directly or indirectly related to bone remodeling. This review provides a brief overview of the research progresses of vascular calcification-related molecular signaling pathways from the perspective of osteoblastic differentiation. Key words: Monckeberg medial calcific sclerosis; Muscle, smooth, vascular