化学
克莱森重排
芳基
区域选择性
二硒醚
多米诺骨牌
产量(工程)
功能群
组合化学
二苯基二硒醚
乙醚
药物化学
有机化学
催化作用
冶金
材料科学
聚合物
硒
烷基
作者
Jiwen Fang,Xiao‐Biao Yan,Wu‐Jie Lin,Yi-Chuan Zhao,Xueyuan Liu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-09-11
卷期号:21 (18): 7635-7638
被引量:17
标识
DOI:10.1021/acs.orglett.9b02942
摘要
A diphenyl-diselenide-mediated Claisen-type rearrangement/cyclization of propargylic aryl ethers under metal-free conditions is developed, affording various naphthofuran-2-carboxaldehydes in moderate to excellent yield. The broad substrate scope and excellent functional group compatibility suggest that it can be a straightforward and powerful method to access naphthofuran-2-carboxaldehydes in a highly regioselective manner. Moreover, this reaction can be scaled up to the gram scale.
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