化学
磺酰
有机合成
灵活性(工程)
键裂
组合化学
有机化学
纳米技术
催化作用
数学
统计
材料科学
烷基
作者
Xue‐Qiang Chu,Danhua Ge,Yan-Ying Cui,Zhi‐Liang Shen,Chao‐Jun Li
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2021-08-13
卷期号:121 (20): 12548-12680
被引量:124
标识
DOI:10.1021/acs.chemrev.1c00084
摘要
As the "chemical chameleon", sulfonyl-containing compounds and their variants have been merged with various types of reactions for the efficient construction of diverse molecular architectures by taking advantage of their incredible reactive flexibility. Currently, their involvement in radical transformations, in which the sulfonyl group typically acts as a leaving group via selective C-S, N-S, O-S, S-S, and Se-S bond cleavage/functionalization, has facilitated new bond formation strategies which are complementary to classical two-electron cross-couplings via organometallic or ionic intermediates. Considering the great influence and synthetic potential of these novel avenues, we summarize recent advances in this rapidly expanding area by discussing the reaction designs, substrate scopes, mechanistic studies, and their limitations, outlining the state-of-the-art processes involved in radical-mediated desulfonylation and related transformations. With a specific emphasis on their synthetic applications, we believe this review will be useful for medicinal and synthetic organic chemists who are interested in radical chemistry and radical-mediated desulfonylation in particular.
科研通智能强力驱动
Strongly Powered by AbleSci AI