上睑下垂
癌症免疫疗法
癌细胞
免疫疗法
癌症研究
化学
材料科学
癌症
程序性细胞死亡
细胞生物学
纳米技术
免疫系统
生物物理学
细胞凋亡
生物
免疫学
生物化学
遗传学
作者
Binbin Ding,Jiyao Sheng,Pan Zheng,Chunxia Li,Dong Liu,Ziyong Cheng,Ping’an Ma,Jun Lin
出处
期刊:Nano Letters
[American Chemical Society]
日期:2021-09-30
卷期号:21 (19): 8281-8289
被引量:98
标识
DOI:10.1021/acs.nanolett.1c02790
摘要
Pyroptosis, which is a mode of programmed cell death, has proven effective for cancer therapy. However, efficient pyroptosis inducers for tumor treatment are limited. This study proposes biodegradable K3ZrF7:Yb/Er upconversion nanoparticles (ZrNPs) as pyroptosis inducers for cancer immunotherapy. ZrNPs, which are similar to ion reservoirs, can be dissolved inside cancer cells and release high amounts of K+ and [ZrF7]3- ions, resulting a surge in intracellular osmolarity and homeostasis imbalance. This further induces an increase in reactive oxygen species (ROS), caspase-1 protein activation, gasdermin D (GSDMD) cleavage, and interleukin-1β (IL-1β) maturity, and results in cytolysis. In vivo tests confirm that ZrNPs-induced pyroptosis exhibits superior antitumor immunity activity confirmed by enhanced dendritic cells (DCs) maturity and frequency of effector-memory T cells, as well as observably inhibiting tumor growth and pulmonary metastasis. This work is believed to extend the biomedical applications of upconversion nanomaterials and deepen the understanding of intrinsic immunomodulatory activity of nanomaterials.
科研通智能强力驱动
Strongly Powered by AbleSci AI