Notch信号通路
癌症研究
生物
血管生成
转移
癌症
刺猬信号通路
信号转导
下调和上调
细胞
细胞生长
基因
细胞生物学
遗传学
作者
Ankit Kumar Pandey,Bhuvanadas Sreeshma,Joel P. Joseph,Rama Jayaraj,Arikketh Devi
出处
期刊:Endocrine, metabolic & immune disorders
[Bentham Science]
日期:2021-12-31
卷期号:21 (12): 2159-2168
被引量:3
标识
DOI:10.2174/1871530321666210421125231
摘要
Cancer, a set of diseases characterized by abnormal cell growth resulting from alteration in the expression pattern of diverse genes, is one of the prominent causes of mortality and morbidity worldwide. This modification of various genes leads to altered signalling cascades and changes in the molecular network. These changes eventually give rise to cellular dysfunction and then to systemic failure causing death. Of the several pathways that are aberrantly activated in cancer, Notch signalling pathway is a prominent one. Notch signalling pathway is a juxtracrine signalling pathway which activates the genes associated with cell proliferation, survival and angiogenesis. Notch signalling pathway components are seen to be upregulated in several types of cancer. Oral squamous cell carcinoma (OSCC) is a predominant category of oral cancer where aberrant activation of Notch signalling causes tumour progression and metastasis. In this review, we discuss the Notch signalling pathway, its components, forms and its role in the progression and metastasis of oral squamous cell carcinoma.
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