脂质体
药物输送
小泡
细胞外小泡
纳米技术
药代动力学
生物相容性材料
胞外囊泡
靶向给药
毒品携带者
药品
化学
生物物理学
药理学
材料科学
微泡
细胞生物学
膜
生物化学
生物
生物医学工程
医学
基因
小RNA
作者
Luke van der Koog,Timea B. Gandek,Anika Nagelkerke
标识
DOI:10.1002/adhm.202100639
摘要
Over the past decades, lipid-based nanoparticle drug delivery systems (DDS) have caught the attention of researchers worldwide, encouraging the field to rapidly develop improved ways for effective drug delivery. One of the most prominent examples is liposomes, which are spherical shaped artificial vesicles composed of lipid bilayers and able to encapsulate both hydrophilic and hydrophobic materials. At the same time, biological nanoparticles naturally secreted by cells, called extracellular vesicles (EVs), have emerged as promising more complex biocompatible DDS. In this review paper, the differences and similarities in the composition of both vesicles are evaluated, and critical mediators that affect their pharmacokinetics are elucidate. Different strategies that have been assessed to tweak the pharmacokinetics of both liposomes and EVs are explored, detailing the effects on circulation time, targeting capacity, and cytoplasmic delivery of therapeutic cargo. Finally, whether a hybrid system, consisting of a combination of only the critical constituents of both vesicles, could offer the best of both worlds is discussed. Through these topics, novel leads for further research are provided and, more importantly, gain insight in what the liposome field and the EV field can learn from each other.
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