创伤性脑损伤
脑震荡
神经影像学
医学
格拉斯哥昏迷指数
脑震荡后综合征
生物标志物
神经科学
心理学
重症监护医学
毒物控制
伤害预防
精神科
急诊医学
生物化学
化学
作者
Valeria Diaz-Pacheco,Javier Vargas‐Medrano,Eric Tran,Meza Nicolas,Diamond Price,Richa Patel,Silvina Tonarelli,Bharathi S. Gadad
摘要
Mild traumatic brain injury (mTBI) is the most prevalent type of TBI (80–90%). It is characterized by a loss consciousness for less than 30 minutes, post-traumatic amnesia for less than 24 hours, and Glasgow Coma Score of 13–15. Accurately diagnosing mTBIs can be a challenge because the majority of these injuries do not show noticeable or visible changes on neuroimaging studies. Appropriate determination of mTBI is tremendously important because it might lead in some cases to post-concussion syndrome, cognitive impairments including attention, memory, and speed of information processing problems. The scientists have studied different methods to improve mTBI diagnosis and enhanced approaches that would accurately determine the severity of the trauma. The present review focuses on discussing the role of biomarkers as potential key factors in diagnosing mTBI. The present review focuses on 1) protein based peripheral and CNS markers, 2) genetic biomarkers, 3) imaging biomarkers, 4) neurophysiological biomarkers, and 5) clinical trials in mTBI. Each section provides information and characteristics on different biomarkers for mTBI.
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