病态的
雄激素受体
内科学
阶段(地层学)
免疫组织化学
医学
多元分析
肿瘤科
生物标志物
孕酮受体
病理
胃肠病学
雌激素受体
癌症
乳腺癌
生物
前列腺癌
古生物学
生物化学
作者
Yang Wu,Shanshan Sun,Yuanxi Huang,Min Xiao,Xinwei Zhao,Xiaobo Lu,Bo Xia,Kun Qiao,Shiyuan Zhang,Qiqi Wu,Jie Xiong,Shaoqiang Cheng,Yanni Song
标识
DOI:10.1007/s00432-022-03988-1
摘要
PurposeLittle is known about the prognostic value of androgen receptor (AR) status in mammary Paget’s disease (MPD). The purpose of this study was to explore AR status and the distribution of molecular subtypes in MPD as well as the relationship between AR expression and clinicopathological factors and to evaluate its prognostic value.MethodsWe analyzed 170 MPD patients of varying subtypes. AR expression was verified by immunohistochemical staining, and the correlations between AR expression and clinicopathological characteristics and survival status were analyzed. We further investigated 91 MPD patients with invasive ductal carcinoma (MPD-IDC).ResultsAR was expressed in 55.3% of overall MPD patients, and 78.2% had the human epidermal growth factor receptor 2 (HER2) overexpression subtype. AR positivity was significantly correlated with BMI (P = 0.037) and pathological N stage (P = 0.023). Multivariate analysis indicated that pathological T stage and pathological N stage were independent prognostic factors for overall survival (OS). The positive AR group was significantly associated with better OS (P = 0.014). Among 91 MPD-IDC patients, AR was expressed in 56.0%, and 80.0% had the HER2 overexpression subtype. AR positivity was significantly correlated with pathological N stage (P = 0.033). Multivariate analysis indicated that AR and pathological T stage were independent prognostic factors for OS. Furthermore, AR positivity was significantly related to better OS (P = 0.005) in MPD-IDC patients as well as in patients with the HER2 overexpression subtype (P = 0.029).ConclusionOur results confirmed that AR is a potential biomarker for evaluating the prognosis of patients.
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