辛迪康1
表型
蛋白多糖
生物
跨膜蛋白
细胞生物学
受体
心力衰竭
细胞
遗传学
医学
内科学
基因
细胞外基质
作者
Faheem Shaik,Michaela, J.M. Balderstone,Samantha Arokiasamy,James R. Whiteford
标识
DOI:10.1016/j.biocel.2022.106196
摘要
The heparan sulphate proteoglycan Syndecan-4 belongs to a 4-member family of transmembrane receptors. Genetic deletion of Syndecan-4 in mice causes negligible developmental abnormalities however when challenged these animals show distinct phenotypes. Synedcan-4 is expressed in many cell types in the heart and its expression is elevated in response to cardiac injury and recent studies have suggested roles for Syndecan-4 in repair mechanisms within the damaged heart. The purpose of this review is to explore these biological insights into the role of Syndecan-4 in both the injured heart and later during cardiac repair and remodeling.
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