类有机物
个性化医疗
精密医学
清脆的
三维细胞培养
转化研究
计算生物学
转化医学
计算机科学
生物
生物信息学
医学
神经科学
细胞培养
病理
生物技术
基因
遗传学
作者
Yu‐Sheng Lin,Liming Jiang,Qiaojun He,Meng Yuan,Ji Cao
标识
DOI:10.1016/j.biopha.2022.112869
摘要
Organoids are in vitro simplified and miniature microcosms of internal organs, which have aroused great interest in tissue development, multiple disease models, clinical diagnosis, as well as high-throughput drug screening and personalized medicine and so on. The success of physiology-related organoid culture has greatly advanced the translational medicine research in the field of cancer treatment, which was once troubled by the inconsistency between two-dimensional (2D) cell culture and in vivo studies. Especially in recent years, the success rate of establish an organoid has been greatly improved, and the types of organoids have been gradually enriched. Moreover, the utilizing of some the cutting-edge technologies, including gene editing technology such as CRISPR-Cas9, the scope of application of organoid is broadened. In this review, we discuss the latest progress and applications of organoids, and also outline the potential challenges of organoids for future improvement.
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