布尼卡
植物化学
抗菌剂
化学
DPPH
赫拉
抗氧化剂
白色念珠菌
传统医学
大肠杆菌
生物利用度
体外
食品科学
生物化学
植物
有机化学
生物
药理学
基因
医学
作者
Jing-Hui Ruan,Jun Li,Guliqire Adili,Guangying Sun,Munire Abuduaini,Rahima Abdulla,Maitinuer Maiwulanjiang,Haji Akber Aisa
标识
DOI:10.1021/acs.jafc.1c08341
摘要
Pomegranate peels, which are normally processed as the main byproduct of pomegranate juice production, are worthy of being researched and utilized for the aim of economic and environmental benefits. In a phytochemical investigation of the peels of Punica granatum L., 10 phenolic compounds containing a common hexahydroxy diphenol moiety were isolated. Three of them were identified for the first time and named as pomegranatins A-C, and from the other seven known ones, two of them were obtained from pomegranate peels for the first time. Their structures were determined via extensive spectroscopic analysis. Besides, for the sake of preliminarily comprehending their biological activities, in vitro antimicrobial, antioxidant, as well as antitumor assays were detected. In the DPPH antioxidant assay, six compounds presented significant free radical scavenging ability. Two compounds exhibited moderate antimicrobial activities against Candida albicans; one compound could inhibit the proliferation of both C. albicans and Escherichia coli within limits. Four compounds possessed weak antitumor activity toward the Hela cell line without taking into account the bioavailability of ellagitannins. Overall, these results provided further information on the structural diversity of bioactive compounds present in pomegranate peels, as well as on their biological activities.
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