Mass spectrometry-based multi-omics analysis elucidates immune microenvironmental characteristics and the risk of distant metastasis in N1c colorectal cancer

We assessed the protein expression profiles and pathway characteristics of N1c CRC. The model developed based on TDRGs, effectively predicted DFS and immunotherapy response, supporting precision treatment and staging system optimization. PLOD1's role in ECM remodeling and CRC cell migration and invasion suggests its potential as a prognostic biomarker and therapeutic target.