Murine Aortopulmonary Shunt Model of Flow-Driven Pulmonary Hypertension—Brief Report

Transcatheter aortopulmonary shunt establishes a minimally invasive, reproducible murine model of shunt-driven pulmonary artery hypertension triggered by flow-mediated arteriopathy. This platform provides a versatile tool to interrogate flow-sensing mechanisms and to evaluate therapies targeting both vasoreactivity and structural remodeling in pulmonary artery hypertension.