Removable Directing Group in Proximal CH Functionalization

This chapter focuses on the role of removable directing groups (RDGs) in enhancing regioselective CH activation reactions via transition-metal catalysis. It addresses the challenges of positional selectivity in CH functionalization and explores solutions provided by RDGs across a wide range of functional groups containing substrates and heteroarenes. Numerous examples demonstrate how traditional functional groups can be converted into powerful directing groups for CH activation. The chapter emphasizes the versatility of RDGs in achieving complex transformations. These advancements significantly contribute to organic synthesis, offering valuable tools for developing complex molecular architectures.