微尺度化学
螺旋(铁路)
动力学
化学
扩散
Crystal(编程语言)
化学物理
晶体生长
原子力显微镜
结晶学
分子动力学
原位
表面扩散
材料科学
纳米技术
吸附
热力学
计算化学
物理
物理化学
经典力学
数学分析
数学教育
数学
有机化学
计算机科学
程序设计语言
作者
Shuhong Song,Lei Wang,Yaqian Qu,Huimin Li,Hongshuai Wang,Peng Han,Zeliang Gao,Xutang Tao
标识
DOI:10.1021/acs.cgd.3c01285
摘要
The crystal growth mechanism of form I (AZ-I) of the antihypertensive drug azilsartan is revealed by in situ atomic force microscopy (AFM). On the dominant (100) face, AZ-I grows by a classical spiral growth mechanism. The growth spiral is asymmetric due to the different step kinetics in different crystallographic directions. The normal growth rate of the (100) face is inferred to be much lower than the step velocity within this face according to the step geometry, resulting in the plate-like crystal morphology. The dependence of step velocity on terrace width indicates that molecules incorporate into steps primarily by a surface diffusion mechanism involving molecular adsorption on terraces at first and then diffusion into steps. Within the (100) face, steps in different directions exhibit different step edge free energies and total minimal energies for step advancement. The step kinetics depends on the step length within a certain range. These findings provide a fundamental understanding of drug crystal growth at the microscale.
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