壳聚糖
伤口愈合
自愈
化学工程
材料科学
纳米技术
化学
医学
外科
工程类
替代医学
病理
作者
K. Kasirajan,Young-Kwon Park,Ravindran Balasubraman,M. Karunakaran,Ganesh Munuswamy-Ramanujam,Soon Woong Chang,Jin‐Heong Yim
标识
DOI:10.1016/j.cej.2024.149088
摘要
Nature-inspired multifunctional composites are suitable materials for tissue reconstruction. Treating bacterial infections and promoting wound healing/skin regeneration remain major concerns in clinical practise and basic research. Single-modal treatment tends to be unreliable. In this study, multipurpose CS/MXene@LDH hybrid nanocomposites (NCs) are manufactured using chitosan functionalized with self-assembled anionic-charged MXene and cationic-charged cobalt tungsten (CoW) layered doubled hydroxide (LDH) to develop promising wound-dressing materials. The physicochemical characteristics of hybrid NCs were investigated using XRD, XPS, FTIR, SEM, and TEM. The in-vitro results reveal that the CS/MXene@LDH hybrid NCs improve wound healing behaviour and acceptable cytocompatibility. Furthermore, in-vivo studies show that the hybrid NCs successfully inhibits the inflammatory response and promote fibroblast growth, granulation tissue formation, deposition of collagen, and re-epithelialisation of skin wounds, resulting in wound healing in mice. These findings indicate that the CS/MXene@LDH hybrid NCs is good candidates for wound-healing applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI