Research progress in the pathogenesis and treatment of premature ovarian failure

Premature ovarian failure (POF) in females Amenorrhea before the age of 40, accompanied by elevated FSH levels (FSH>40 U/L), decreased estrogen levels, and other endocrine abnormalities and menopause Form; Refers to premature and complete failure of ovarian function. POF is a highly heterogeneous clinical disease with a mixed etiology. The occurrence of premature ovarian failure is related to abnormalities in granulosa cells, genetic factors, immune factors, mitochondrial dysfunction, environmental factors, and personal habits. The main signs and symptoms of POF include hot flashes, night sweats, facial skin flushing, decreased libido, vaginal dryness, genital atrophy, menstrual irregularities or amenorrhea. May be accompanied by diseases such as osteoporosis and infertility. The clinical treatment of premature ovarian failure often uses artificial cycle therapy with estrogen and progesterone. Although the effect is fast, it is easy to relapse after stopping the medication and requires long-term drug treatment, with significant adverse reactions. In recent years, research has found that traditional Chinese medicine has significant effects in delaying and protecting ovarian function in immune premature ovarian failure. This article explores the etiology, clinical manifestations, pathogenesis, ovarian histological changes, and related treatments of premature ovarian failure.