光热治疗
血栓
溶栓
材料科学
血栓形成
纳米颗粒
氧化铁纳米粒子
纳米技术
荧光寿命成像显微镜
生物医学工程
体内
医学
荧光
外科
内科学
生物技术
物理
心肌梗塞
生物
量子力学
作者
Karla X. Vazquez‐Prada,Shehzahdi S. Moonshi,Yuao Wu,Fahima Akther,Brian Wan-Chi Tse,Kamil A. Sokolowski,Karlheinz Peter,Xiaowei Wang,Gordon Xu,Hang T. Ta
出处
期刊:Small
[Wiley]
日期:2023-01-12
卷期号:19 (11)
被引量:19
标识
DOI:10.1002/smll.202205744
摘要
Abstract Thrombosis and its complications are responsible for 30% of annual deaths. Limitations of methods for diagnosing and treating thrombosis highlight the need for improvements. Agents that provide simultaneous diagnostic and therapeutic activities (theranostics) are paramount for an accurate diagnosis and rapid treatment. In this study, silver‐iron oxide nanoparticles (AgIONPs) are developed for highly efficient targeted photothermal therapy and imaging of thrombosis. Small iron oxide nanoparticles are employed as seeding agents for the generation of a new class of spiky silver nanoparticles with strong absorbance in the near‐infrared range. The AgIONPs are biofunctionalized with binding ligands for targeting thrombi. Photoacoustic and fluorescence imaging demonstrate the highly specific binding of AgIONPs to the thrombus when functionalized with a single chain antibody targeting activated platelets. Photothermal thrombolysis in vivo shows an increase in the temperature of thrombi and a full restoration of blood flow for targeted group but not in the non‐targeted group. Thrombolysis from targeted groups is significantly improved ( p < 0.0001) in comparison to the standard thrombolytic used in the clinic. Assays show no apparent side effects of AgIONPs. Altogether, this work suggests that AgIONPs are potential theranostic agents for thrombosis.
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