Silver-catalyzed radical bisphosphonation reaction of maleimides with diarylphosphine oxides

A silver-catalyzed bisphosphonate reaction of substituted maleimides with various diarylphosphine oxides was developed. This methodology provided an efficient strategy to prepare phosphorus–containing succinimide derivatives with satisfactory yields. The reaction exhibited mild reaction conditions and good functional group compatibilities. The radical species induced pathway was also demonstrated by mechanistic studies.