药物输送
生物医学工程
八达通(软件)
粘附
材料科学
抽吸
医学
纳米技术
化学
机械工程
工程类
计算化学
复合材料
作者
Zunlue Zhu,Jian Wang,Xibo Pei,Junyu Chen,Xinwei Wei,Yanhua Liu,Pengcheng Xia,Qianbing Wan,Zhen Gu,Yong He
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2023-06-23
卷期号:9 (25)
被引量:21
标识
DOI:10.1126/sciadv.adh2213
摘要
Intratissue topical medication is important for the treatment of cutaneous, mucosal or splanchnic diseases. However, penetrating surface barriers to providing adequate and controllable drug delivery while guaranteeing adhesion in bodily fluids remains challenging. Here, the predatory behavior of the blue-ringed octopus inspired us with a strategy to improve topical medication. For effective intratissue drug delivery, the active injection microneedles were prepared in a manner inspired by the teeth and venom secretion of blue-ringed octopus. With on demand release function guided by temperature-sensitive hydrophobic and shrinkage variations, these microneedles can supply adequate drug delivery at an early stage and then achieve the long-term release stage. Meanwhile, the bionic suction cups were developed to facilitate microneedles to stay firmly in place (>10 kilopascal) when wet. With wet bonding ability and multiple delivery mode, this microneedle patch achieved satisfactory efficacy, such as accelerating the ulcers’ healing speed or halting early tumor progression.
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