A randomized crossover design study comparing the pharmacokinetics and pharmacodynamics of 2 single doses of oral aspirin (75 mg v 150 mg) in pregnant women at risk of preeclampsia: implications on assessing aspirin response and patient adherence to therapy

Compared to the 75-mg dose, 150 mg of aspirin more effectively inhibits thromboxane B₂, providing rationale for further investigation of effectiveness of higher doses for preeclampsia prevention. Despite limitations, measuring serum SA concentration could still be used in future models to test adherence if done within 11 to 12 hours after ingestion.