被盖腹侧区
多巴胺
不确定地带
神经科学
食物消费
心理学
多巴胺能
生物
丘脑
农业经济学
经济
作者
Qiying Ye,Jeremiah Nunez,Xiaobing Zhang
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2023-11-15
卷期号:9 (46)
标识
DOI:10.1126/sciadv.adi5326
摘要
Energy deprivation triggers food seeking to ensure homeostatic consumption, but the neural coding of motivational vigor in food seeking during physical hunger remains unknown. Here, we report that ablation of dopamine (DA) neurons in zona incerta (ZI) but not ventral tegmental area potently impaired food seeking after fasting. ZI DA neurons and their projections to paraventricular thalamus (PVT) were quickly activated for food approach but inhibited during food consumption. Chemogenetic manipulation of ZI DA neurons bidirectionally regulated feeding motivation to control meal frequency but not meal size for food intake. Activation of ZI DA neurons promoted, but silencing of these neurons blocked, contextual memory associate with food reward. In addition, selective activation of ZI DA projections to PVT promoted food seeking for food consumption and transited positive-valence signals. Together, these findings reveal that ZI DA neurons encode motivational vigor in food seeking for food consumption through their projections to PVT.
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