Fundamental crosstalk between circadian rhythm and the intestine in the pathogenesis of inflammatory bowel disease

Crohn's disease (CD) and ulcerative colitis (UC) are the main representatives of inflammatory bowel disease (IBD), which is a chronic, relapsing inflammatory disease of the gastrointestinal tract mediated by the immune system. The pathogenesis of IBD is still not fully clarified. Currently, several studies have reported that circadian abnormality has profound effects on the immune system and intestinal microflora. Meanwhile, it is widely accepted that immune function and intestinal microbiota are two major factors in the pathogenesis of IBD. However, the role of the circadian rhythm in relation to IBD is relatively less understood and largely unexplored. The aim of this review is to present the current state of knowledge about the relationship between circadian rhythm disorders, sleep disturbance, and IBD to analyze the possibility of employing this knowledge in IBD diagnosis and treatment.