化学
次氯酸盐
分子内力
光化学
水溶液
荧光
部分
粘度
亚砜
吩噻嗪
荧光团
斯托克斯位移
红移
电子转移
分析化学(期刊)
二甲基亚砜
滴定法
作者
Junyan Ma,Xiangtao Kong,Mingtao Zhao,Yi‐Sheng Liu,Dan Meng,Zhenxing Zhang,Fenglin Wang
标识
DOI:10.1021/acs.analchem.5c02894
摘要
In this study, a novel phenothiazine-cyanoacetate-based fluorescent probe, NS-CY, was developed for the simultaneous detection of hypochlorite (ClO-), oxyammonia (NH2OH), and viscosity, utilizing triresponse signals. Initially, the probe exhibits red fluorescence at 642 nm under aqueous media. In high-viscosity environments, the inhibition of intramolecular bond rotation within NS-CY activates the fluorescence emission at 492 nm, resulting in strong green fluorescence. Concurrently, ClO--induced oxidation of the phenothiazine moiety to a sulfoxide product causes a significant blue shift in emission from 642 to 548 nm, generating yellow fluorescence. Upon reacting with oxyammonia, the fluorescence at 642 nm decreases gradually, which exhibits a turn-off pattern. Furthermore, the probe was successfully applied to monitor viscosity increases induced by ferroptosis caused by erastin in living cells. Notably, NS-CY effectively tracked both ClO- and oxyammonia in zebrafish, which demonstrates its potential application in related early diagnosis and medical intervention.
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