A Global Population-Based Study on the Association Between Ketamine and Esketamine With Suicidality Using WHO VigiBase

Conclusion: Both increased and decreased RORs for suicidality parameters were observed with ketamine and esketamine, with similar results regardless of whether lithium or fluoxetine was used as the reference. However, causality between ketamine/esketamine use and changes in suicidality cannot be determined.