叶下珠
化学
槲皮素
杨梅素
传统医学
类黄酮
糖苷
立体化学
生物化学
医学
山奈酚
抗氧化剂
作者
Jia Xu,Ying Xin,Hongtao Zhu,Qinghua Kong,Wei-Nong Yang,Dong Wang,Chong‐Ren Yang,Yingjun Zhang
标识
DOI:10.1080/14786419.2022.2116704
摘要
Eleven flavonoids including one new flavonol glycoside, quercetin-3-O-(2-α-L-rhamnopyranosyl)-β-D-glucuronopyranosyl methyl ester (1), were isolated for the first time from the fruits of Phyllanthus acidus (L.) Skeels (Phyllanthaceae). Their structures were determined by extensive spectroscopic data. The known flavonoids, quercetin-3-O-β-D-glucuronide methyl ester (3), quercetin-3-O-(2''-α-L-rhamnopyranosyl-6''-O-α-L-rhamno pyranosyl)-β-D-glucopyranoside (5), myricetin (9), and 6-methoxy-naringenin (11) were isolated for the first time from the genus Phyllanthus. Flavonoids 4, 6 and 9 (IC50 = 6.01, 6.32, and 7.84 μM, respectively) showed stronger α-glucosidase inhibitory activities than the positive control, acarbose (IC50 = 306.45 μM). The fruits of P. acidus might be further developed as an anti-diabetic food supplement.
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