脊髓
硬膜外腔
神经调节
后肢
神经科学
刺激
脊髓损伤
医学
运动功能
背
解剖
生物
物理医学与康复
作者
Dingchang Lin,Jung Min Lee,Chonghe Wang,Hong‐Gyu Park,Charles M. Lieber
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-06-20
卷期号:23 (13): 6184-6192
标识
DOI:10.1021/acs.nanolett.3c01806
摘要
Spinal cord neuromodulation can restore partial to complete loss of motor functions associated with neuromotor disease and trauma. Current technologies have made substantial progress but have limitations as dorsal epidural or intraspinal devices that are either remote to ventral motor neurons or subject to surgical intervention in the spinal tissue. Here, we describe a flexible and stretchable spinal stimulator design with nanoscale thickness that can be implanted by minimally invasive injection through a polymeric catheter to target the ventral spinal space of mice. Ventrolaterally implanted devices exhibited substantially lower stimulation threshold currents and more precise recruitment of motor pools than did comparable dorsal epidural implants. Functionally relevant and novel hindlimb movements were achieved via specific stimulation patterns of the electrodes. This approach holds translational potential for improving controllable limb function following spinal cord injury or neuromotor disease.
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