安慰剂
胆固醇
置信区间
随机化
载脂蛋白B
医学
随机对照试验
低密度脂蛋白胆固醇
脂蛋白
风险因素
胃肠病学
内分泌学
内科学
替代医学
病理
作者
Stephen J. Nicholls,Adam J. Nelson,Marc Ditmarsch,John J.P. Kastelein,Christie M. Ballantyne,Kausik K. Ray,Ann Marie Návar,Steven E. Nissen,Mariko Harada‐Shiba,Danielle Curcio,Annie Neild,Douglas Kling,Andrew Hsieh,Julie Butters,Brian A. Ference,Ulrich Laufs,Maciej Banach,Roxana Mehran,Alberico L. Catapano,Yong Huo
标识
DOI:10.1056/nejmoa2415820
摘要
Among patients with atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia who were receiving maximum tolerated doses of lipid-lowering therapy and were at high risk for cardiovascular events, obicetrapib reduced LDL cholesterol levels by 29.9%. (Funded by NewAmsterdam Pharma; BROADWAY ClinicalTrials.gov number, NCT05142722.).
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