脂质体
类风湿性关节炎
医学
免疫系统
关节炎
炎症
药理学
佐剂
免疫学
化学
生物化学
作者
Scott Poh,Venkatesh Chelvam,Lindsay E. Kelderhouse,Wilfredo Ayala-López,Balasubramanian Vaitilingam,Karson S. Putt,Philip S. Low
出处
期刊:Nanomedicine
日期:2017-10-01
卷期号:12 (20): 2441-2451
被引量:31
标识
DOI:10.2217/nnm-2017-0166
摘要
Aim: We endeavored to create a folate-targeted liposome (Fol-liposome) that could selectively target areas of inflammation. Materials & methods: Fol-liposomes were prepared with encapsulated DiD fluorophore or betamethasone (BM) to image and treat an adjuvant-induced rat model of rheumatoid arthritis. Results: Fol-liposomes selectively accumulated in arthritic rat paws to a greater extent than nontargeted liposomes. When these Fol-liposomes were used to encapsulate BM and administered to arthritic rats, animals exhibited less paw swelling, lower arthritis scores, a reduction in bone erosion, less splenomegaly and better maintenance of body weight when compared with nontreated or nontargeted BM-containing liposome groups. Conclusion: Fol-liposomes can selectively deliver imaging and therapeutic agents to sites of inflammation in a rat model of rheumatoid arthritis.
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