The effect of metformin on expression of vaspin mRNA in insulin resistant rats induced by high-fat diet

High-fat diet-induced insulin resistance rat model was assessed by euglycemic-hyperinsulinemic clamp technique.Compared with the control group,the vaspin mRNA expression in adipose tissue was significantly decreased in insulin resistant rats induced by high-fat diet( P＜0.05 ),which was increased by metformin( P＜0.05 ).These data indicate that metformin may ameliorate insulin resistance in rats via upregulating vaspin mRNA expression. Key words: Insulin resistance; Vaspin; Metformin; Euglycemic-hyperinsulinemic clamp; Rats