适体
碱基
核酸
化学空间
模块化设计
计算机科学
组合化学
纳米技术
计算生物学
化学
DNA
药物发现
生物
材料科学
遗传学
生物化学
操作系统
作者
Fabian Tölle,Gerhard M. Brändle,Daniel Matzner,Günter Mayer
标识
DOI:10.1002/anie.201503652
摘要
Abstract A novel and versatile method has been developed for modular expansion of the chemical space of nucleic acid libraries, thus enabling the generation of nucleobase‐modified aptamers with unprecedented recognition properties. Reintroduction of the modification after enzymatic replication gives broad access to many chemical modifications. This wide applicability, which is not limited to a single modification, will rapidly advance the application of in vitro selection approaches beyond what is currently feasible and enable the generation of aptamers to many targets that have so far not been addressable.
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