化学
结合
环己烷类
分子内力
级联
产量(工程)
组合化学
立体化学
配体(生物化学)
对映选择合成
作者
Katsumi Nishimura,Naoshi Fukuyama,Tomohisa Yasuhara,Mitsuaki Yamashita,Takaaki Sumiyoshi,Yasutomo Yamamoto,Ken-ichi Yamada,Kiyoshi Tomioka
出处
期刊:Tetrahedron
[Elsevier]
日期:2015-09-30
卷期号:71 (39): 7222-7226
被引量:14
标识
DOI:10.1016/j.tet.2015.03.014
摘要
Abstract The chiral diether ligand-controlled asymmetric conjugate addition of organolithiums to nona-2,7-dienedioate and subsequent intramolecular conjugate addition of the enolate intermediate gave all-trans trisubstituted cyclohexanes with high ee and yields. Using this methodology, an efficient short asymmetric total synthesis of (+)-β-lycorane was accomplished in 33% overall yield through five steps from the dienedioate.
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