生物分析
分析物
工作流程
纳米技术
生化工程
色谱法
化学
医学物理学
计算机科学
医学
材料科学
工程类
数据库
作者
Martijn Hilhorst,Peter van Amsterdam,Katja Heinig,Elke Zwanziger,Richard Abbott
出处
期刊:Bioanalysis
[Newlands Press Ltd]
日期:2015-02-01
卷期号:7 (3): 333-343
被引量:19
摘要
In bioanalysis of small molecules, the analyte concentration in the measured samples should reflect the concentration during sample collection. Precautions may be needed to prevent over- or under-estimation of the obtained result. This might require the addition of stabilizers to prevent degradation or nonspecific binding. For unstable drugs, it is essential to know how analytes can be stabilized before the start of the clinical study. Although the stabilization methods are well documented, the impact of the stabilization on the clinical workflow is not properly addressed. Already during method development, the clinical implications in terms of personnel safety, ease of use, training possibilities and staff capacity should be taken into account, and validation of the bioanalytical method should reflect collection procedures.
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