Electrochemical Direct Fluorination of Lactams

Abstract The electrochemical fluorination of a variety of N ‐protected lactams was carried out and Et 3 N–5HF was found to be superior to Et 3 N–3HF as the electrolyte. When 5‐ and 6‐membered N ‐acetyl or ethoxycarbonyl lactams were used as substrates, the fluorination reaction selectively took place at the α‐position of the lactam nitrogen and the corresponding monofluoro products could be obtained in good yields.