瑞舒伐他汀
蛋白尿
内科学
血脂异常
排泄
肌酐
内分泌学
医学
β-2微球蛋白
尿
泌尿系统
泌尿科
肾功能
他汀类
肾
糖尿病
作者
Michael S. Kostapanos,Haralampos Milionis,Irene F. Gazi,Christina Kostara,Eleni Bairaktari,Moses Elisaf
标识
DOI:10.1177/0091270006292629
摘要
The renoprotective effect of statins has been recently disputed because of observations of proteinuria associated with rosuvastatin treatment, the newest drug of the class. Statin‐induced proteinuria findings were mainly based on crudely quantitative dipstick assays. The authors quantitatively evaluated the effect of rosuvastatin at the recommended starting dose of 10 mg/d, on urine protein excretion in patients with primary dyslipidemia. Serum lipid and nonlipid parameters as well as urinary electrolyte, creatinine, and protein (total, albumin, immunoglobulin G, and α‐1 microglobulin) levels were measured in 40 patients treated with rosuvastatin and 30 controls at baseline and after 12 weeks. The protein‐to‐creatinine ratios were used to assess urinary protein excretion. Rosuvastatin improved the lipid profile, produced no deterioration of kidney function, but induced a small but significant increase in the excretion of α‐1 microglobulin (by 16%, P < .05) indicating that statin‐related proteinuria involves low‐molecular‐weight proteins and is of proximal tubular origin.
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