医学
病理
钙化
营养不良钙化
软骨母细胞瘤
成骨细胞瘤
纤维瘤
结缔组织
间充质干细胞
骨化
骨软化症
巨细胞
巨细胞瘤
骨肉瘤
解剖
骨质疏松症
作者
Noel Weidner,Daniel Santa Cruz
出处
期刊:Cancer
[Wiley]
日期:1987-04-15
卷期号:59 (8): 1442-1454
被引量:314
标识
DOI:10.1002/1097-0142(19870415)59:8<1442::aid-cncr2820590810>3.0.co;2-q
摘要
Reported are the pathologic features of 17 mesenchymal tumors documented as causing osteomalacia or rickets. Although these tumors were histologically polymorphous, they were classifiable into four morphological groups. In the first group there were ten unique tumors showing mixed connective tissue features and containing variably prominent vascular and/or osteoclast-like giant-cell components. Tumors of this group also displayed focal microcystic changes, osseous metaplasia, and/or poorly developed cartilaginous areas. The cartilaginous areas sometimes showed considerable dystrophic calcification. With one exception, all tumors of this group occurred in soft tissue and demonstrated benign clinical behavior. The single malignant tumor originated in bone, recurred locally, and metastasized to lung. The tumors comprising the remaining three groups (six tumors) occurred in bone, demonstrated benign clinical behavior, and were grouped according to their close resemblance to tumors known to occur in bone, that is osteoblastoma-like (four tumors), nonossifying fibroma-like (two tumors), and ossifying fibroma-like (one tumor).
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