Ratiometric MRI Sensors Based on Core–Shell Nanoparticles for Quantitative pH Imaging

Ratiometric MRI sensors consist of paramagnetic cores and pH-sensitive polymer shells. The core–shell nanostructure enables the coexistence of two incompatible NMR relaxation properties in one particle. The sensors show pH sensitivity in transverse relaxivity (r2), but not in longitudinal relaxivity (r1). Quantitative pH imaging is achieved by measuring the r2/r1 value with a clinical 3 T MRI scanner. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.