The reaction of 4‐(p‐nitrobenzyl)pyridine with some electrophiles

Abstract The nucleophile 4‐(p‐nitrobenzyl)pyridine was allowed to react with four carcinogenic alkylating agents, chloromethyl methyl ether, bis(chloromethyl) ether, glycol sulfate and propane sultone, one carcinogenic acylating agent, N,N‐dimethylcarbamyl chloride, and one noncarcinogenic electrophile, perchlorocyclobutenone. The structures of the major products formed, which are substituted pyridinium salts or 1,4‐dihydropyridines, were determined.