羽扇豆醇
抗氧化剂
一氧化氮
化学
脂质过氧化
糖尿病
氧化应激
硫代巴比妥酸
活性氧
内科学
丙二醛
生物化学
药理学
内分泌学
医学
有机化学
作者
R. Gupta,Anil Kumar Sharma,Madhulika Sharma,M. P. Dobhal,R. Gupta
标识
DOI:10.1080/14786419.2011.560845
摘要
Oxidative stress, produced under diabetic conditions, is a possible cause of various forms of tissue damage. The concentrations of antioxidant enzymes in cases of diabetes are significantly decreased, with a concomitant increase in lipid peroxidation. In this study, lupeol, a phytoconstituent from Solanum xanthocarpum, is shown to suppress the progression of diabetes after 21 days. Lupeol treatment caused decreases in glycated haemoglobin, serum glucose and nitric oxide, with a concomitant increase in serum insulin level. Furthermore, treatment with lupeol also increased antioxidant levels, with a decrease in the level of thiobarbituric acid-reactive oxygen species.
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