医学
间质液
血管生成
放射治疗
化疗
生物标志物
病理
肿瘤科
癌症研究
内科学
化学
生物化学
作者
Sarah Jane Lunt,Anthony Fyles,Richard P. Hill,Michael Milosevic
出处
期刊:Future Oncology
[Future Medicine]
日期:2008-12-01
卷期号:4 (6): 793-802
被引量:111
标识
DOI:10.2217/14796694.4.6.793
摘要
Interstitial fluid pressure is elevated in virtually all solid malignant tumors as a result of abnormalities of the vasculature and interstitium. High interstitial fluid pressure is an independent predictor of disease recurrence in cervical cancer patients treated with radiotherapy, has been implicated as an important factor that impairs the delivery of chemotherapy to tumors and may influence the regulation and distribution of cytokines and growth factors. Targeted molecular treatments that inhibit angiogenesis or alter interstitial fluid dynamics also produce early reductions in interstitial fluid pressure. Reductions in interstitial fluid pressure due to anti-angiogenic treatment have been associated with improved therapeutic outcome in preclinical studies when these agents are combined with radiotherapy or conventional cytotoxic chemotherapy. Pretreatment interstitial fluid pressure and the change in pressure during treatment may provide important predictive information that in the future will be used to optimize therapy in individual patients.
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