免疫系统
癌症研究
药理学
免疫调节
医学
免疫学
化学
生物
作者
Stanleyson V. Hato,I. Jolanda M. de Vries,W. Joost Lesterhuis
出处
期刊:OncoImmunology
[Informa]
日期:2012-03-01
卷期号:1 (2): 234-236
被引量:31
标识
DOI:10.4161/onci.1.2.18126
摘要
Platinum-based anticancer drugs enhance the immunostimulatory potential of DCs and decrease the immunosuppressive capacity of tumor cells. This immunomodulatory ability is based on the inhibition of STAT6-mediated expression of co-inhibitory molecule PD-L2 and opens up the possibility of using these drugs in combination with other immunostimulatory compounds.
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