神经炎症
海马体
海马结构
神经科学
突触可塑性
微塑料
化学
医学
生物
受体
内科学
炎症
环境化学
作者
Chiang‐Wen Lee,Lee-Fen Hsu,I‐Lin Wu,Yung‐Li Wang,Wei-Chen Chen,Yanjun Liu,Lu-Tang Yang,Chong-Lun Tan,Yueh Hsia Luo,Chia-Ching Wang,Hsiao-Yean Chiu,Thomas C.-K. Yang,Yi‐Bing Lin,Hsin‐An Chang,Yu-Ting Chiang,Ching-Hsiang Chen,Ming-Hsueh Lee,Kuo-Ti Peng,Cathy Chia-Yu Huang
标识
DOI:10.1016/j.jhazmat.2022.128431
摘要
Microplastics (MPs) pollution has become a serious environmental issue worldwide, but its potential effects on health remain unknown. The administration of polystyrene MPs (PS-MPs) to mice for eight weeks impaired learning and memory behavior. PS-MPs were detected in the brain especially in the hippocampus of these mice. Concurrently, the hippocampus had decreased levels of immediate-early genes, aberrantly enhanced synaptic glutamate AMPA receptors, and elevated neuroinflammation, all of which are critical for synaptic plasticity and memory. Interestingly, ablation of the vagus nerve, a modulator of the gut-brain axis, improved the memory function of PS-MPs mice. These results indicate that exposure to PS-MPs in mice alters the expression of neuronal activity-dependent genes and synaptic proteins, and increases neuroinflammation in the hippocampus, subsequently causing behavioral changes through the vagus nerve-dependent pathway. Our findings shed light on the adverse impacts of PS-MPs on the brain and hippocampal learning and memory.
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