医学
急性肾损伤
肾毒性
肾脏替代疗法
肾
重症监护医学
2019年冠状病毒病(COVID-19)
肾脏疾病
内科学
作者
James Hilton,Naomi Boyer,Mitra K. Nadim,Lui G. Forni,John A. Kellum
标识
DOI:10.1016/j.ccc.2022.01.002
摘要
Initial reporting suggested that kidney involvement following COVID-19 infection was uncommon but this is now known not to be the case. Acute kidney injury (AKI) may arise through several mechanisms and complicate up to a quarter of patients hospitalized with COVID-19 infection being associated with an increased risk for both morbidity and death. Mechanisms of injury include direct kidney damage predominantly through tubular injury, although glomerular injury has been reported; the consequences of the treatment of patients with severe hypoxic respiratory failure; secondary infection; and exposure to nephrotoxic drugs. The mainstay of treatment remains the prevention of worsening kidney damage and in some cases they need for renal replacement therapies (RRT). Although the use of other blood purification techniques has been proposed as potential treatments, results to-date have not been definitive.
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