光动力疗法
光热治疗
脂质体
葡萄糖氧化酶
癌症研究
药物输送
热休克蛋白
声动力疗法
光敏剂
生物物理学
化学
材料科学
医学
纳米技术
生物化学
生物
酶
有机化学
基因
作者
Yuqiong Xia,Yufeng Wu,Jianxia Cao,Jun Wang,Zhao‐Xu Chen,Cairu Li,Xianghan Zhang
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2022-04-11
卷期号:8 (5): 1892-1906
被引量:9
标识
DOI:10.1021/acsbiomaterials.1c01311
摘要
Organic near-infrared fluorescent dye mediated photothermal therapy (PTT) and photodynamic therapy (PDT) suffer from heat shock response, since, heat shock proteins (HSPs) are overexpressed and can repair the proteins damaged by PTT and PDT. Starvation therapy by glucose oxide (GOx) can inhibit the heat shock response by limiting the energy supply. However, the delivery of sufficient and active GOx remains a challenge. To solve this problem, we utilize liposomes as drug carriers and prepare GOx loaded liposome (GOx@Lipo) with a high drug loading content (12.0%) and high enzymatic activity. The successful delivery of GOx shows excellent inhibition of HSPs and enhances PTT and PDT. Additionally, we apply the same liposome formulation to load near-infrared dye 1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbo cyanine iodide (DiR) and prepare DiR contained liposomes (DiR@Lipo) for PTT and PDT. The liposomal formulation substantially enhances the PTT and PDT properties of DiR as well as the cellular uptake and tumor accumulation. Finally, the combination therapy shows excellent tumor inhibition on 4T1 tumor-bearing mice. Interestingly, we also find that the starvation therapy can efficiently inhibit tumor metastasis, which is probably due to the immunogenic effect. Our work presents a biocompatible and effective carrier for the combination of starvation therapy and phototherapy, emphasizing the importance of auxiliary starvation therapy against tumor metastasis and offering important guidance for clinical PTT and PDT.
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