脂肪生成
脂滴
脂筏
细胞生物学
脂肪细胞
脂质代谢
内化
CD36
生物
脂肪酸
基因敲除
下调和上调
MAPK/ERK通路
化学
生物化学
信号转导
脂肪组织
细胞
受体
基因
细胞凋亡
间充质干细胞
作者
Shao-Chin Wu,Yuan-Ming Lo,Jui-Hao Lee,Chin-Yau Chen,Tung-Wei Chen,Hong‐Wen Liu,Wei-Nan Lian,Kate Hua,Chi Chang Liao,Win-Li Lin,Chih‐Yung Yang,Chien-Yi Tung,Chi‐Hung Lin
标识
DOI:10.1038/s41467-022-31825-z
摘要
Abstract Regulation of fatty acid uptake, lipid production and storage, and metabolism of lipid droplets (LDs), is closely related to lipid homeostasis, adipocyte hypertrophy and obesity. We report here that stomatin, a major constituent of lipid raft, participates in adipogenesis and adipocyte maturation by modulating related signaling pathways. In adipocyte-like cells, increased stomatin promotes LD growth or enlargements by facilitating LD-LD fusion. It also promotes fatty acid uptake from extracellular environment by recruiting effector molecules, such as FAT/CD36 translocase, to lipid rafts to promote internalization of fatty acids. Stomatin transgenic mice fed with high-fat diet exhibit obesity, insulin resistance and hepatic impairments; however, such phenotypes are not seen in transgenic animals fed with regular diet. Inhibitions of stomatin by gene knockdown or OB-1 inhibit adipogenic differentiation and LD growth through downregulation of PPAR γ pathway. Effects of stomatin on PPAR γ involves ERK signaling; however, an alternate pathway may also exist.
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