Pd-catalyzed cross-coupling of terminal alkynes with ene-yne-ketones: access to conjugated enynes via metal carbene migratory insertion

A novel strategy for alkyne-alkyne cross-coupling has been developed under the palladium catalysis. In this reaction, ene-yne-ketones are employed as carbene precursors, which couple with terminal alkynes through the metal carbene migratory insertion process. Furan-substituted enynes are obtained in good yields and in a stereoselective manner.