SOCS2
癌症研究
反义RNA
癌变
生物
细胞生长
甲状腺癌
肿瘤进展
细胞
基因
分子生物学
抑制器
核糖核酸
甲状腺
遗传学
作者
Xiaojian Zhang,Xiaozhou Zhang,Guangxiao Yang,Long Wan,Feng-yan Yin,Hongqiang Li,Dengke Yin
标识
DOI:10.1016/j.bbrc.2023.05.080
摘要
Long noncoding RNAs (lncRNAs) have been shown to contribute to tumorigenesis and cancer progression. However, neither the dysregulation nor the functions of anti-sense lncRNAs in papillary thyroid carcinoma (PTC) have been exhaustively studied. In this study, we accessed The Cancer Genome Atlas (TCGA) database and discovered that the natural antisense lncRNA SOCS2-AS1 is highly expressed in PTC and that patients with a higher level of SOCS2-AS1 had a poor prognosis. Furthermore, loss- and gain-function assays demonstrated that SOCS2-AS1 promotes PTC cell proliferation and growth both in vitro and in vivo. In addition, we demonstrated that SOCS2-AS1 regulates the rate of fatty acid oxidation (FAO) in PTC cells. Analysis of the mechanism revealed that SOCS2-AS1 binds to p53 and controls its stability in PTC cell lines. Overall, our findings showed that the natural antisense lncRNA SOCS2-AS1 stimulates the degradation of p53 and enhances PTC cell proliferation and the FAO rate.
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